Научни публикации

Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting

Twenty international FP experts belonging to the American Society of Reproductive Medicine, ESHRE and the International Society of Fertility Preservation reviewed the literature up to June 2015 to be discussed at the meeting, and approved the final manuscript. At the time this manuscript was being written, new evidence considered relevant for the debated topics was published, and was consequently included.


The Expert Working Group made the following recommendations:

  • Several oncological and non-oncological diseases may affect current or future fertility, either due to the disease itself or to gonadotoxic
    treatment, and need an adequate FP approach. These patients should be counselled regarding potential fertility loss and should be
    referred to fertility specialists to discuss options for FP and current results.
  • Women wishing to postpone maternity and transgender individuals before starting hormone therapy or undergoing surgery to remove/
    alter their reproductive organs, should also be counselled accordingly.
  • Embryo and oocyte cryopreservation are first-line FP methods in post-pubertal women. Metaphase II oocyte cryopreservation (vitrification) is the preferred option.
  • Cumulative evidence of restoration of ovarian function and spontaneous pregnancies after ART following orthotopic transplantation
    of cryopreserved ovarian tissue supports its future consideration as an open clinical application.
  • Semen cryopreservation is the only established FP technique in men.
  • Testicular tissue cryopreservation should be recommended in prepubertal boys even though fertility restoration strategies by autotransplantation of cryopreserved testicular tissue have not yet been tested for safe clinical use in humans.
  • The establishment of international registries on the short- and longterm outcomes of FP techniques is strongly recommended.
female fertility preservation options Martinez et al 2015